Alzheimer's Disease N-F—AD7c-NTP in POClia

Alzheimer's disease (AD) is a central nervous system degenerative disease characterized by progressives cognitive impairment, which leads to the fifth major cause of death among the elderly, and there is no special effective treatment yet. AD7C-NTP is a transmembrane phosphoprotein closely related to the degeneration of AD neurons, which can promote the germination of neuroinflammation and apoptosis. It is selectively elevated in the brain tissue, cerebrospinal fluid and urine of patients with AD in the early stage. However, similar specific increase has not been found in multiple sclerosis, depression, and other chronic diseases.The sensitivity and specificity of AD7C-NTP in urine for the diagnosis of AD were similar to those in cerebrospinal fluid, and the content of AD7C-NTP in urine was positively correlated with the severity of dementia. In addition, urine detection is easy to operate, non-invasive, economic, safe, and other advantages, convenient for clinical application, urine AD7c-NTP may become a specific biomarker for screening and diagnosis of AD in the future.

EXPLANATION OF THE TEST

The Alzheimer-related neurofilament protein AD7c-NTP, belonging to the neurofilament protein family, is elevated in the brain tissue, cerebrospinal fluid and urine of early AD patients, and is significantly correlated with neuronal degeneration and damage. Its content is proportional to the severity of dementia, and these characteristics make it an important marker for the early diagnosis of AD.
Its biggest advantage is that it can detect changes in AD7c-NTP levels in urine, overcoming the shortcomings of various invasive tests.

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Zecen Biotech CO., LTD., founded in 2011, is a leading Chinese diagnostics manufacturer specializing in in-vitro diagnostics devices and reagents. Zecen focus on the Chemiluminescent immunoassay (CLIA) field. With all products CE marked, our market presence currently spreads from across China to other countries including India, Switzerland, Russia etc., Zecen is expanding its footprint to become a global brand.

Zecen is the only enterprise with independent intellectual property rights in the entire chemiluminescence industry chain in China, including reagent, instrument, magnetic microbead, and reagent raw material. Our current products include more than 100 assays, from thyroid, inflammation, diabetes, tumer markers, immune disorders, hormones to cardiac markers. Our ever-expanding test menu helps our customers and collaborators keep up with the demands of healthcare sector. Zecen is striving for innovation and perfection to deliver the best products to the customers.

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