Procollagen I of Aminoterminal Propeptide(PINP)for Automatic immunoassay analyzer in Bone Metabolism

Bone type I collagen is the most abundant form of collagen in the body, comprising approximately 90% of bone mass.

Type I collagen is mainly synthesized in bone tissue. Procollagen is synthesized first. There is an extension peptide at the amino N-terminus and C-terminus of type I procollagen, which are respectively called Type I procollagen N-terminal propeptide (PINP). and type I procollagen C-terminal propeptide (PICP); when type I procollagen is secreted out of the cell by osteoblasts, the N-terminal and C-terminal extended peptides are cleaved by proteases, and in addition to a small amount deposited in the bone matrix, a large amount of It enters the blood circulation and is eventually metabolized and eliminated by the liver. Therefore, under the exclusion of liver disease, the detection of PINP content in blood can accurately reflect the activity of osteoblasts, which in turn reflects the intensity of bone metabolism in the body, and guides the diagnosis and treatment of diseases caused by abnormal bone metabolism.

Zecen Biotech CO., LTD., founded in 2011, is a leading Chinese diagnostics manufacturer specializing in in-vitro diagnostics devices and reagents. Zecen focus on the Chemiluminescent immunoassay (CLIA) field. With all products CE marked, our market presence currently spreads from across China to other countries including India, Switzerland, Russia etc., Zecen is expanding its footprint to become a global brand.

Zecen is the only enterprise with independent intellectual property rights in the entire chemiluminescence industry chain in China, including reagent, instrument, magnetic microbead, and reagent raw material. Our current products include more than 100 assays, from thyroid, inflammation, diabetes, tumer markers, immune disorders, hormones to cardiac markers. Our ever-expanding test menu helps our customers and collaborators keep up with the demands of healthcare sector. Zecen is striving for innovation and perfection to deliver the best products to the customers.

As a manufacturer, Zecen provide the OEM, ODM and other customized service of all products. We have the core R&D centers and innovative ability to lay a solid foundation for developing the broadest range of CLIA analyzers and test menu. High-quality sales and after-sales links provide the more intimate service. The patent and CE certification give us the confident sending all over the world, and more than 50 companys in the requiement of customized and have a long term coorperation with Zecen.